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ea0092op-04-01 | Oral Session 4: Young Investigators / Clinical and Translational | ETA2023

Interaction between DIO2 polymorphisms and LT4 treatment on psychological well-being outcomes and cardiovascular risk factors: a population-based cross-sectional study in uk biobank

Zinck Jensen Christian , Lynggaard Isaksen Jonas , Ahlberg Gustav , Salling Olesen Morten , Nygaard Birte , Ellervik Christina , Kim Kanters Jorgen

Objectives: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. We investigated, as previously hypothesized, if single nucleotide polymorphisms (SNPs) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the Deiodinase 2 gene (DIO2), or rs17606253 in the Monocarboxylate Transporter 10 gene (MCT10) were associated with outcomes indicative of local tissue hypothyroidism in LT4-tre...

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Endocrine Abstracts

Interaction between DIO2 polymorphisms and LT4 treatment on psychological well-being outcomes and cardiovascular risk factors: a population-based cross-sectional study in uk biobank

BiosciAbstracts